Roxyzin 10mg Tablet

Uses of

It is used to treat:

• Allergic reactions
• Itching due to urticaria (nettle rash) and dermatitis
• Anxiety

Side Effects of

• Mood changes
• Restlessness
• Confusion
• Hallucinations
• Shaking
• Difficulty urinating
• Fast or irregular heartbeat
• Drowsiness
• Dizziness
• Blurred vision
• Dry mouth
• Constipation
• Rashes
• Severe allergic reactions
• Itching
• Swelling
• Blurred vision

How does

Hydroxyzine is an Antihistaminic Medication. In allergy, it works by blocking the action of a chemical messenger (histamine). This relieves allergy symptoms such as itching, swelling, and rashes. In short-term anxiety, it works by decreasing the activity in the brain, thereby helping you feel relaxed/sleepy.

Quick Suggestions:

• Roxyzin 10mg Tablet is a medication used to manage various allergic skin conditions and to alleviate symptoms of mild anxiety.
• It is important to follow your doctor's instructions and not exceed the prescribed duration of treatment.
• Taking Roxyzin 10mg Tablet may result in decreased alertness, so it is advisable to refrain from driving or operating machinery if you experience this side effect.
• Additionally, alcohol consumption should be avoided while taking Roxyzin 10mg Tablet, as it can lead to excessive sleepiness or drowsiness. Inform your doctor if you have a history of heart disease, as Roxyzin 10mg Tablet may increase the risk of heart problems.
• It is important to disclose any prior diagnoses of kidney or liver problems to your doctor.
• Elderly patients should exercise caution when using Roxyzin 10mg Tablet, as the side effects may be more pronounced.
• This medication may cause dizziness, so it is recommended to avoid driving or engage in activities that require alertness.
• Before starting treatment with Roxyzin 10mg Tablet, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, and provide a detailed medical history.
• In case of an overdose, promptly seek medical assistance by contacting your doctor.

Indication

Roxyzin 10mg acts as an antidepressant and provides relief in cases of anxiety or tension. It is a sedative that lowers the activity of the nervous system. It also works as an antihistamine. Roxyzin 10mg Tablet is also used to cure certain skin allergies.

It can also be used in combination with other medications for the purpose of anesthesia.

Pharmacology

Hydroxyzine, which belongs to the piperazine derivative class, acts by blocking histamine H1-receptors on various effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. It is classified as a sedating antihistamine with additional antimuscarinic properties, meaning it can inhibit the effects of acetylcholine in certain parts of the body. Hydroxyzine is known for its significant sedative effects, making it useful for promoting relaxation and reducing anxiety. In addition to its antihistamine and sedative properties, hydroxyzine also exhibits skeletal muscle relaxing effects, acts as a bronchodilator to widen the airways, has antiemetic properties to prevent or alleviate nausea and vomiting and possesses analgesic properties to help relieve pain.

Dosage & Administration of

For adults, the recommended oral doses of hydroxyzine are as follows:

1. For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: 50-100 mg is taken four times daily.
2. For the management of pruritus (itching) due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus: Initially, 25 mg taken at night, which can be increased up to 25 mg taken 3-4 times daily if needed.
3. As a sedative when used as a premedication and following general anesthesia: 50-100 mg.

In cases of hepatic impairment, the total daily dose should be reduced by 33%.

For children, the recommended oral doses of hydroxyzine are as follows:

For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested:

• Children under 6 years: 50 mg daily in divided doses.
• Children over 6 years: 50 to 100 mg daily in divided doses.

For the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus:

• Children:
  • 6 months to 6 years: Initially, 5-15 mg/day, increased to 50 mg/day in divided doses.
  • Over 6 years: Initially, 15-25 mg/day, increased up to 50-100 mg/day in divided doses.

As a sedative when used as a premedication and following general anesthesia: 0.6 mg/kg in children.

In cases of hepatic impairment, the total daily dose should be reduced by 33%.

For individuals with renal impairment, dose adjustment is as follows:

• Renal impairment with a glomerular filtration rate (GFR) of >50 mL/min: No dose adjustment necessary.
• Renal impairment with a GFR of <50 mL/min: Administer 50% of the normal dose.

Always follow the dosage instructions provided by your physician and do not exceed the prescribed duration of use.

Interaction

Interaction with Alcohol: It is not recommended to consume alcohol while taking this medicine as it may result in dizziness and difficulty in concentration. Engaging in activities that require mental alertness, such as driving or operating machinery, should be avoided.

Interaction with Lab Test: Information about interactions with specific lab tests is not available. It is advisable to consult with your doctor or healthcare provider for more information.

Interaction with Medicine:

1. Clozapine: Co-administration of hydroxyzine with clozapine may increase the risk of irregular heart rhythm. Close monitoring of symptoms such as palpitations, breathing difficulty, and dizziness is necessary. Dose adjustments may be required if both medications are used together.
2. Ketoconazole: Taking hydroxyzine with ketoconazole may increase the risk of irregular heart rhythm. It is important to monitor for symptoms such as palpitations, breathing difficulty, and dizziness. Adjustments to the doses of these medications may be necessary if they are used together.
3. Antihypertensives: Caution should be exercised when using hydroxyzine with antihypertensive medications as it may lower blood pressure. Inform your doctor if you experience symptoms such as dizziness or lightheadedness. The dose of any of these medicines may need to be adjusted based on your clinical condition.
4. Fluoroquinolone antibiotics: Co-administration of hydroxyzine with fluoroquinolone antibiotics may increase the risk of irregular heart rhythm. If you are receiving quinolone antibiotics, inform your doctor. They may consider an alternative medicine based on your clinical condition.

Interaction with Disease:

1. QT Prolongation: Hydroxyzine is not recommended for patients with a history of QT prolongation and existing heart disease. Alternative medicine should be considered based on your clinical condition.

Interaction with Food: Information regarding interactions with food is not available. It is advisable to follow your doctor's instructions and maintain a healthy and balanced diet.

Please note that the above information is not exhaustive, and other potential interactions may exist. It is essential to inform your doctor about all the medications, supplements, and medical conditions you have before starting hydroxyzine or making any changes to your treatment.

Contraindications

• Allergy: If you are allergic to hydroxyzine, other antiallergic medicines, or any other ingredients present in Roxyzin 10mg Tablet, you should avoid using it.
• Irregular heart rhythms and family history of sudden death: If you have a history of irregular heart rhythms or if there is a family history of sudden death due to a heart disorder, Roxyzin 10mg Tablet should be avoided.
• Cardiovascular disease and low heart rate: If you have or have had cardiovascular disease or if your heart rate is very low, it is not recommended to use Roxyzin 10mg Tablet.
• Liver or kidney failure: Roxyzin 10mg Tablet should be avoided if you have liver or kidney failure, as it may worsen the condition.
• Narrow-angle glaucoma: If you have an eye disorder called narrow-angle glaucoma, the use of Roxyzin 10mg Tablet is contraindicated.
• Prostate problems with urine retention: If you have a prostate problem that causes urine retention, the use of Roxyzin 10mg Tablet should be avoided.
• Use of brain-related disorder medications: If you are taking medications used to treat brain-related disorders, such as monoamine oxidase inhibitors like selegiline or phenelzine, Roxyzin 10mg Tablet should not be used concurrently.
• Children below 12 months of age: Roxyzin 10mg Tablet is not recommended for children below 12 months of age.
• Porphyria: If you have porphyria, a condition characterized by stomach pain, constipation, change in urine color, skin rashes, and disturbing behavior, Roxyzin 10mg Tablet should be avoided.
• Pregnancy and breast-feeding: Roxyzin 10mg Tablet is contraindicated during pregnancy, if you may be pregnant, or if you are breastfeeding. It is important to consult with your doctor regarding alternative treatment options.

Pregnancy & Lactation

The safety of hydroxyzine in early pregnancy is not well established due to insufficient human clinical data. Therefore, it is contraindicated in early pregnancy until more data becomes available.

Regarding breastfeeding, hydroxyzine is not known to be excreted in human milk. However, it is recommended to avoid administering hydroxyzine to nursing women because many medications are eliminated quickly and can potentially affect the nursing infant.

It's important to consult with your healthcare provider before taking any medication during pregnancy or while breastfeeding. They can provide you with the most up-to-date and appropriate information based on your specific situation.

Precautions & Warnings

• Before taking hydroxyzine, it is important to inform your doctor or pharmacist about any allergies you may have, including allergies to hydroxyzine, cetirizine, levocetirizine, or any other substances. This medication may contain inactive ingredients that can cause allergic reactions or other issues. It is advisable to consult with your pharmacist for more information.
• Provide your doctor or pharmacist with your medical history, particularly if you have breathing problems (such as asthma or emphysema), glaucoma (high pressure in the eye), high blood pressure, kidney problems, liver problems, seizures, stomach or intestinal problems (such as ulcers or blockage), overactive thyroid, or difficulty urinating due to an enlarged prostate.
• Hydroxyzine has the potential to cause a condition called QT prolongation, which affects the heart rhythm. QT prolongation can rarely lead to severe, sometimes fatal, fast or irregular heartbeat and other symptoms such as severe dizziness or fainting. Seek immediate medical attention if you experience these symptoms. The risk of QT prolongation may be increased if you have certain medical conditions or if you are taking other medications known to cause QT prolongation. Inform your doctor about all the medications you are taking and if you have a history of certain heart problems or a family history of such problems.
• Hydroxyzine can cause dizziness, drowsiness, and blurred vision. Alcohol can intensify these effects. Avoid driving, operating heavy machinery, or engaging in activities that require alertness or clear vision until you can do so safely. It is also important to discuss marijuana (cannabis) use with your doctor if applicable.
• Liquid forms of hydroxyzine may contain sugar or alcohol. If you have diabetes, liver disease, or any condition that requires you to limit or avoid these substances in your diet, exercise caution.
• Children may be more sensitive to the serious side effects of this medication. Instead of causing drowsiness, hydroxyzine can sometimes cause excitement in young children.
• Older adults may be more prone to experiencing side effects, particularly drowsiness, confusion, constipation, difficulty urinating, or QT prolongation. Sleepiness and confusion can increase the risk of falling.
• Hydroxyzine should only be used during pregnancy when absolutely necessary. Consult your doctor regarding the risks and benefits of using this medication while pregnant.
• It is unclear whether this drug is transferred into breast milk. Consult your doctor before breastfeeding.

Storage Conditions

Place in a cool, dry location. Protect yourself from the sun. Keep out of children's reach.